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抗高血压药物对心室肥厚的消退有不同的影响。

Anti-hypertensive drugs have different effects on ventricular hypertrophy regression.

机构信息

Departamento de Clínica Médica, Faculdade de Medicina do ABC, Santo André/SP, Brasil.

出版信息

Clinics (Sao Paulo). 2010 Jul;65(7):723-8. doi: 10.1590/S1807-59322010000700012.

DOI:10.1590/S1807-59322010000700012
PMID:20668631
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2910862/
Abstract

OBJECTIVES

There is a direct relationship between the regression of left ventricular hypertrophy (LVH) and a decreased risk of mortality. This investigation aimed to describe the effects of anti-hypertensive drugs on cardiac hypertrophy through a meta-analysis of the literature.

METHODS

The Medline (via PubMed), Lilacs and Scielo databases were searched using the subject keywords cardiac hypertrophy, antihypertensive and mortality. We aimed to analyze the effect of anti-hypertensive drugs on ventricle hypertrophy.

RESULTS

The main drugs we described were enalapril, verapamil, nifedipine, indapamina, losartan, angiotensin-converting enzyme inhibitors and atenolol. These drugs are usually used in follow up programs, however, the studies we investigated used different protocols. Enalapril (angiotensin-converting enzyme inhibitor) and verapamil (Ca(++) channel blocker) caused hypertrophy to regress in LVH rats. The effects of enalapril and nifedipine (Ca(++) channel blocker) were similar. Indapamina (diuretic) had a stronger effect than enalapril, and losartan (angiotensin II receptor type 1 (AT1) receptor antagonist) produced better results than atenolol (selective beta1 receptor antagonist) with respect to LVH regression.

CONCLUSION

The anti-hypertensive drugs induced various degrees of hypertrophic regression.

摘要

目的

左心室肥厚（LVH）的消退与死亡率降低之间存在直接关系。本研究旨在通过对文献的荟萃分析来描述抗高血压药物对心脏肥大的影响。

方法

使用主题关键词“cardiac hypertrophy”、“antihypertensive”和“mortality”，在 Medline（通过 PubMed）、Lilacs 和 Scielo 数据库中进行检索。我们旨在分析抗高血压药物对心室肥大的影响。

结果

我们描述的主要药物有依那普利、维拉帕米、硝苯地平、吲达帕胺、氯沙坦、血管紧张素转换酶抑制剂和阿替洛尔。这些药物通常用于随访方案，但我们研究的研究使用了不同的方案。依那普利（血管紧张素转换酶抑制剂）和维拉帕米（Ca(++)通道阻滞剂）可使 LVH 大鼠的肥大消退。依那普利和硝苯地平（Ca(++)通道阻滞剂）的作用相似。吲达帕胺（利尿剂）的作用强于依那普利，氯沙坦（血管紧张素 II 受体 1 型（AT1）受体拮抗剂）的效果优于阿替洛尔（选择性β1 受体拮抗剂），可使 LVH 消退。

结论

抗高血压药物引起了不同程度的肥大消退。

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