新型正电荷 (99m)Tc(I)-三羰基配合物 [(99m)Tc-15C5-PNP] 的动力学特征及其在心肌灌注成像中的应用。
Kinetic characterization of a novel cationic (99m)Tc(I)-tricarbonyl complex, (99m)Tc-15C5-PNP, for myocardial perfusion imaging.
机构信息
Department of Radiology, University of Arizona, P.O. Box 245067, Tucson, AZ 85724-5067, USA.
出版信息
J Nucl Cardiol. 2010 Oct;17(5):858-67. doi: 10.1007/s12350-010-9262-y. Epub 2010 Jul 29.
BACKGROUND
Intense liver uptake of (99m)Tc-sestamibi (MIBI) often interferes with visualization of myocardial perfusion in the inferior wall of the left ventricle. To develop improved myocardial perfusion agents, crown ether-containing dithiocarbamates and bisphosphines have been introduced in recent years. This study was designed to investigate the myocardial imaging properties and in vivo kinetics of a cationic (99m)Tc(I)-tricarbonyl complex, (99m)Tc-15C5-PNP, in comparison with MIBI.
METHODS
Dynamic cardiac images were acquired for 60 minutes after intravenous tracer injection using a small-animal SPECT system in healthy control rats and rats with myocardial infarcts. Myocardial and liver time-activity curves were generated for radiopharmaceutical kinetic analysis.
RESULTS
Good visualization of the left ventricular wall and perfusion defects could be achieved 20 minutes after (99m)Tc-15C5-PNP administration. (99m)Tc-15C5-PNP images in all hearts with infarcts showed perfusion defects, which were comparable to MIBI images. The kinetic curves plotted from 1 to 60 minutes demonstrated that (99m)Tc-15C5-PNP has a shorter washout half-life (6.4 ± 3.2 vs 124 ± 30.5 minutes, P < .01) in the liver, lower residual liver activity (14.5 ± 10.2% vs 36.5 ± 28.9%, P < .01), and higher heart/liver ratio than MIBI.
CONCLUSIONS
(99m)Tc-15C5-PNP has potential for rapid myocardial perfusion imaging with low liver uptake.
背景
（99m）Tc- sestamibi（MIBI）在肝脏的摄取量较高，这常常会干扰左心室下壁心肌灌注的显影。为了开发出更好的心肌灌注显影剂，近年来引入了冠醚二硫代氨基甲酸盐和双膦酸盐。本研究旨在研究阳离子（99m）Tc（I）-三羰基配合物（99m）Tc-15C5-PNP 的心肌成像特性和体内动力学，并与 MIBI 进行比较。
方法
在健康对照大鼠和心肌梗死大鼠中，使用小动物 SPECT 系统在静脉注射示踪剂后 60 分钟内采集动态心脏图像。为放射性药物动力学分析生成心肌和肝脏时间-活性曲线。
结果
（99m）Tc-15C5-PNP 给药后 20 分钟即可良好地显影左心室壁和灌注缺损。所有梗死心脏的（99m）Tc-15C5-PNP 图像均显示出灌注缺损，与 MIBI 图像相当。从 1 分钟到 60 分钟绘制的动力学曲线表明，（99m）Tc-15C5-PNP 在肝脏中的洗脱半衰期较短（6.4±3.2 分钟比 124±30.5 分钟，P<.01），残留的肝脏活性较低（14.5±10.2%比 36.5±28.9%，P<.01），心脏/肝脏比值高于 MIBI。
结论
（99m）Tc-15C5-PNP 具有快速心肌灌注成像和肝脏摄取低的潜力。
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