Ward M M, Studenski S
Department of Medicine, Duke University Medical Center, Durham, NC.
J Rheumatol. 1991 Apr;18(4):535-9.
Acute psychotic manifestations in systemic lupus erythematosus (SLE) have been considered usually to occur early in the course of illness, although these findings are primarily based on studies with few patients and limited lengths of observation. To further investigate the chronology of acute psychiatric disturbances in SLE, the time course of these episodes was examined in 36 patients over a median duration of observation of 72 months. Twenty-two of 36 (61.1%) initial psychiatric episodes occurred within the first year of diagnosis of SLE, although several patients experienced the initial onset of psychiatric manifestations several years after the onset of SLE. Recurrent episodes occurred in 10 of 36 patients at a median of 8 months after the initial episode. Although tending to occur early in SLE, primary acute psychiatric events may first occur in patients with long durations of illness, and the time of onset of these episodes does not appear helpful in their differential diagnosis.
系统性红斑狼疮（SLE）中的急性精神病性表现通常被认为在疾病过程早期出现，尽管这些发现主要基于对少数患者的研究且观察时间有限。为了进一步研究SLE中急性精神障碍的时间顺序，对36例患者进行了为期72个月的中位观察，以检查这些发作的时间进程。36例患者中有22例（61.1%）最初的精神发作发生在SLE诊断后的第一年内，尽管有几位患者在SLE发病数年之后才首次出现精神症状。36例患者中有10例出现复发发作，中位时间为首次发作后的8个月。虽然原发性急性精神事件倾向于在SLE早期发生，但也可能首先出现在病程较长的患者中，而且这些发作的起病时间似乎对其鉴别诊断并无帮助。
