Zhu Hong-jun, Lu Shu, Su Wei
Department of Wuxi Cardiology, Hospital Affiliated to Nanjing University of Traditional Chinese Medicine, Jiangsu.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2010 Apr;30(4):361-4.
To observe the intervention effects of Liandou Qingmai Recipe (LQR) on atherogenic indices of plasma (AIP) and high-sensitivity c-reactive protein (hs-CRP) level in patients with coronary heart disease (CHD).
Sixty-eight CHD patients were randomly assigned to two groups, 35 patients in the treatment group and 33 in the control group, all were treated by the regular CHD treatment, but to patients in the treatment group, LQR was given additionally. AIP value was calculated before and after treatment through measuring plasma levels of triglyceride (TG), high-density and low-density lipoprotein cholesterol (HDL-C and LDL-C). Besides, the levels of hs-CRP and peripheral blood leucocyte (PBL) were observed as well.
No significant difference existed between groups in all the detected parameters before treatment (P > 0.05). After treatment, levels of LDL-C, HDL-C, hs-CRP and PBL lowered significantly in the control group, but the changes of AIP and TG were insignificant (P > 0.05); while in the treatment group, all the parameters lowered significantly, with the levels of AIP, TG, hs-CRP and PBL significantly lower than those in the control group respectively (P < 0.05).
LQR can decrease levels of AlP and hs-CRP in CHD patients, amplify the diameters of LDL-C granule, and further lower hs-CRP and PLB levels, showing anti-atherosclerosis and anti-inflammation effects.
观察连豆清脉方（LQR）对冠心病（CHD）患者血浆致动脉粥样硬化指数（AIP）及高敏C反应蛋白（hs-CRP）水平的干预作用。
将68例冠心病患者随机分为两组，治疗组35例，对照组33例，两组均采用冠心病常规治疗，治疗组在此基础上加用连豆清脉方。通过检测血浆甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）水平，计算治疗前后的AIP值。此外，还观察了hs-CRP和外周血白细胞（PBL）水平。
治疗前两组各项检测指标比较，差异无统计学意义（P>0.05）。治疗后，对照组LDL-C、HDL-C、hs-CRP和PBL水平均显著降低，但AIP和TG变化不明显（P>0.05）；治疗组各项指标均显著降低，AIP、TG、hs-CRP和PBL水平分别显著低于对照组（P<0.05）。
连豆清脉方可降低冠心病患者AIP和hs-CRP水平，增大LDL-C颗粒直径，进一步降低hs-CRP和PLB水平，具有抗动脉粥样硬化和抗炎作用。
