阿尔奇霉素 A，一种来自链霉菌属的具有前所未有骨架的生物活性多环聚酮化合物。

Alchivemycin A, a bioactive polycyclic polyketide with an unprecedented skeleton from Streptomyces sp.

机构信息

Biotechnology Research Center, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan.

出版信息

Org Lett. 2010 Aug 6;12(15):3402-5. doi: 10.1021/ol1012982.

PMID:20670006

Abstract

Alchivemycin A, a novel polycyclic polyketide, was isolated from the culture extract of a plant-derived actinomycete Streptomyces sp. The structure and relative configuration were elucidated by spectroscopic analysis and X-ray crystallography, and the absolute configuration was determined by a (1)H NMR anisotropy method using MPA ester derivatization. The new compound contains an unprecedented heterocyclic ring system, 2H-tetrahydro-4,6-dioxo-1,2-oxazine. Alchivemycin A showed potent antimicrobial activity against Micrococcus luteus and inhibitory effects on tumor cell invasion.

摘要

阿霉素 A，一种新型多环聚酮化合物，从植物来源放线菌链霉菌属的培养提取物中分离得到。其结构和相对构型通过光谱分析和 X 射线晶体学阐明，并通过使用 MPA 酯衍生化的（1）H NMR 各向异性方法确定绝对构型。该新化合物含有一个前所未有的杂环体系，2H-四氢-4,6-二氧代-1,2-恶嗪。阿霉素 A 对藤黄微球菌表现出很强的抗菌活性，并对肿瘤细胞侵袭具有抑制作用。