Bishara Ashgan, Rudi Amira, Goldberg Israel, Aknin Maurice, Neumann Drorit, Ben-Califa Nathalie, Kashman Yoel
School of Chemistry, Tel AViV UniVersity, Ramat AViV 69978, Israel.
Org Lett. 2009 Aug 20;11(16):3538-41. doi: 10.1021/ol9011019.
A novel nitrogenous bismacrolide, designated tausalarin C (1), was isolated from the Madagascar sponge Fascaplysinopsis sp. The structure of the compound was elucidated by interpretation of MS and 1D and 2D NMR spectra. It is suggested that tausalarin C is assembled from salarin A (2) and pretaumycin A. The relative configuration of the chiral centers of salarin A was determined by X-ray diffraction. Tausalarin C was found to inhibit proliferation of K562 leukemia cells. A possible biogenesis is discussed.
从马达加斯加海绵Fascaplysinopsis sp.中分离出一种新型含氮双大环内酯，命名为tausalarin C（1）。通过对质谱以及一维和二维核磁共振谱的解析阐明了该化合物的结构。据推测，tausalarin C是由salarin A（2）和前陶霉素A组装而成。通过X射线衍射确定了salarin A手性中心的相对构型。发现tausalarin C可抑制K562白血病细胞的增殖。并讨论了一种可能的生物合成途径。
