Department of Pathology and Cell Biology, University of South Florida, Palmetto, FL 34221, USA.
Arch Pathol Lab Med. 2010 Aug;134(8):1215-9. doi: 10.5858/2008-0620-RS.1.
Basaloid follicular hamartoma is a benign lesion of important consideration because it can be mistaken both clinically and histologically for basal cell carcinoma. The formation of basaloid follicular hamartoma has been linked to a mutation in the patched gene, which is part of the same pathway implicated in nevoid basal cell carcinoma syndrome. While these hamartomas are considered benign lesions, malignant growths have been reported to arise within them, which raises the question, "Is basaloid follicular hamartoma a premalignant lesion?" Correct identification allows for periodic monitoring for malignant transformation, while sparing patients unnecessary surgery. Treatment strategies, including experimental therapies, are reviewed.
基底细胞样滤泡性错构瘤是一种需要高度重视的良性病变，因为它在临床上和组织学上都可能被误诊为基底细胞癌。基底细胞样滤泡性错构瘤的形成与 patched 基因的突变有关，该基因是神经嵴发育不良性基底细胞癌综合征所涉及的同一途径的一部分。虽然这些错构瘤被认为是良性病变，但据报道其中也会出现恶性生长，这就提出了一个问题，“基底细胞样滤泡性错构瘤是否是一种癌前病变？”正确识别可以进行定期监测，以防止恶性转化，同时避免患者接受不必要的手术。本文还回顾了治疗策略，包括实验性治疗。
