Roth L, King J M, Tennant B C
Department of Comparative and Experimental Pathology, College of Veterinary Medicine, University of Florida, Gainesville 32610.
J Wildl Dis. 1991 Apr;27(2):281-7. doi: 10.7589/0090-3558-27.2.281.
Livers from 128 captive woodchucks (Marmota monax) that were negative for serological markers of woodchuck hepatitis virus (WHV) were examined grossly and histologically. Livers from 19 additional seronegative woodchucks were examined only grossly. The most common finding (61% of histological specimens) was mononuclear cells in portal areas. Moderate to severe portal infiltrates in association with similar scattered mononuclear cell aggregates and extramedullary hematopoiesis, were present in woodchucks that had extrahepatic inflammatory lesions. We concluded that these changes represent a response to a variety of chronic infections and are not specific for WHV infection. Other findings included parasitic granulomas, focal and diffuse lipidosis, bile duct proliferation, lesions secondary to cardiovascular compromise, and vasculitis. Two woodchucks had neoplastic lesions.
对128只圈养土拨鼠（旱獭）的肝脏进行了大体和组织学检查，这些土拨鼠的土拨鼠肝炎病毒（WHV）血清学标志物呈阴性。另外19只血清阴性土拨鼠的肝脏仅进行了大体检查。最常见的发现（61%的组织学标本）是门管区的单核细胞。有肝外炎性病变的土拨鼠存在中度至重度门管浸润，并伴有类似的散在单核细胞聚集和髓外造血。我们得出结论，这些变化代表了对多种慢性感染的反应，并非WHV感染所特有。其他发现包括寄生性肉芽肿、局灶性和弥漫性脂质沉积、胆管增生、心血管损害继发的病变以及血管炎。两只土拨鼠有肿瘤性病变。
