硒补充剂对前列腺癌男性患者血清葡萄糖水平没有影响。
No effect of selenium supplementation on serum glucose levels in men with prostate cancer.
机构信息
Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, USA.
出版信息
Am J Med. 2010 Aug;123(8):765-8. doi: 10.1016/j.amjmed.2010.02.018.
BACKGROUND
Literature indicates a relationship between selenium supplementation and risk of diabetes. However, because these data are inconclusive, we investigated the effect of selenium supplementation on serum glucose levels in men with prostate cancer enrolled in a clinical trial testing of the effect of selenium on prostate cancer progression.
METHODS
Subjects were randomized to receive placebo (n=46), selenium 200 microg/day (n=47), and selenium 800 microg/day (n=47). Serum glucose levels were obtained every 6 months for up to 5 years. Longitudinal analysis was carried out to assess whether rate of change of serum glucose levels was significantly different in the selenium-supplemented groups as compared with placebo. Sensitivity analyses were performed to assess the robustness of findings.
RESULTS
Changes in serum glucose levels during the course of the trial were not statistically significantly different as compared with placebo for the selenium 200 microg/day (P=.56) or selenium 800 microg/day (P=.91) treatment groups.
CONCLUSION
These results do not support a relationship between selenium supplementation and changes in serum glucose levels. Recommendations about selenium supplementation and risk of diabetes will require more definitive studies.
背景
文献表明硒补充剂与糖尿病风险之间存在关联。然而，由于这些数据尚无定论，我们研究了硒补充剂对参加临床试验的前列腺癌男性患者血清葡萄糖水平的影响，该试验旨在检测硒对前列腺癌进展的影响。
方法
受试者被随机分配接受安慰剂（n=46）、每天 200 微克硒（n=47）和每天 800 微克硒（n=47）。每 6 个月测量一次血清葡萄糖水平，最长达 5 年。进行纵向分析以评估补充硒的组与安慰剂组相比，血清葡萄糖水平的变化率是否有显著差异。进行敏感性分析以评估结果的稳健性。
结果
与安慰剂相比，每天 200 微克硒（P=.56）或每天 800 微克硒（P=.91）治疗组的试验过程中血清葡萄糖水平的变化无统计学意义。
结论
这些结果不支持硒补充与血清葡萄糖水平变化之间的关系。关于硒补充剂和糖尿病风险的建议需要更明确的研究。
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