HIV-1 在唾液中脱落与口腔和全身健康的相关性。
Oral and systemic health correlates of HIV-1 shedding in saliva.
机构信息
Division of Periodontology, Diagnostic Sciences and Dental Hygiene, 925 West 34th Street, DEN 4320, Herman Ostrow School of Dentistry of USC, University of Southern California, Los Angeles,CA 90089-0641, USA.
出版信息
J Dent Res. 2010 Oct;89(10):1074-9. doi: 10.1177/0022034510375290. Epub 2010 Jul 29.
The relationship among oral and systemic health and HIV shedding in saliva is not well-understood. We hypothesized that oral and systemic health are associated with HIV shedding in saliva of HIV-infected women. Saliva from 127 participants enrolled in the Women's Interagency HIV Study (WIHS) was collected at repeated visits over a 5½-year study period (October 1998 through March 2004) and was evaluated for HIV-1 RNA. Demographic, lifestyle, and systemic and oral health characteristics were evaluated as possible correlates of salivary HIV-1 shedding. Multivariate models showed significantly increased risk of HIV-1 shedding in saliva as blood levels of CD4 cell counts decreased (p < 0.0001) and HIV RNA increased (p < 0.0001). Diabetes (p = 0.002) and a high proportion of gingival bleeding sites (p = 0.01) were associated with increased likelihood, while anti-retroviral therapy (p = 0.0003) and higher levels of stimulated saliva flow rates (p = 0.02) were associated with a lower likelihood of HIV-1 RNA shedding in saliva.
口腔和全身健康与唾液中 HIV 脱落之间的关系尚未得到很好的理解。我们假设口腔和全身健康与 HIV 感染妇女唾液中 HIV 脱落有关。在为期 5 年半的研究期间（1998 年 10 月至 2004 年 3 月），从参加妇女机构间艾滋病毒研究（WIHS）的 127 名参与者中收集了唾液，并对其进行了 HIV-1 RNA 评估。评估了人口统计学、生活方式以及全身和口腔健康特征，以确定其是否与唾液 HIV-1 脱落有关。多变量模型显示，随着血液中 CD4 细胞计数的降低（p < 0.0001）和 HIV RNA 的增加（p < 0.0001），唾液中 HIV-1 脱落的风险显著增加。糖尿病（p = 0.002）和牙龈出血部位比例高（p = 0.01）与增加的可能性相关，而抗逆转录病毒治疗（p = 0.0003）和刺激唾液流速升高（p = 0.02）与降低的可能性相关。HIV-1 在唾液中的 RNA 脱落。
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