Fujii T, Tanaka M, Nakatsuka T, Yoshimura K, Hirose Y, Hirayama J, Kobayashi T, Handa K
First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1991 Mar;29(3):345-52.
Using ventilatory lung motion imaging, which was obtained from two perfusion lung scintigrams with 99mTc-macroaggregated albumin taken in maximal inspiration and maximal expiration, the lung motion [E-I)/I) of the each unilateral lung was studied in various cardiopulmonary diseases. The sum of (E-I)/I(+) of the unilateral lung showed a decrease in the diseased lung of localized pleuropulmonary diseases, including primary lung cancer and pleural thickening, and in both lungs in cases of heart diseases, diffuse pulmonary diseases including diffuse interstitial pneumonia and diffuse panbronchiolitis. The sum of (E-I)/I(+) of the both lungs, which correlated with vital capacity and PaO2, showed a decrease in diffuse interstitial pneumonia, pulmonary emphysema, diffuse panbronchiolitis, primary lung cancer, pleural diseases and so on. (E-I)/I(+), correlated with pulmonary perfusion (n = 49, r = 0.51, p less than 0.001), but not a few cases showed mismatch, which was observed in primary lung cancer, pleural diseases, pulmonary emphysema, diffuse panbronchiolitis and so on. (E-I)/I(+) better correlated with pulmonary ventilation by ventilation scintigraphy with 81mKr or 133Xe (n = 49, r = 0.61, p less than 0.001) than pulmonary perfusion. The ventilatory lung motion imaging, which demonstrates the motion of the intra-pulmonary areas and lung edges, appears useful for estimating pulmonary ventilation of the perfused area as well as pulmonary perfusion.
利用通气肺运动成像技术（该技术通过在最大吸气和最大呼气时摄取的两张99mTc-大聚合白蛋白灌注肺闪烁图获得），对各种心肺疾病中各单侧肺的肺运动[（E-I）/I]进行了研究。单侧肺的（E-I）/I（+）总和在局部胸膜肺部疾病（包括原发性肺癌和胸膜增厚）的患病肺中以及在心脏病、包括弥漫性间质性肺炎和弥漫性细支气管炎的弥漫性肺部疾病的双肺中均显示降低。与肺活量和动脉血氧分压相关的双肺（E-I）/I（+）总和在弥漫性间质性肺炎、肺气肿、弥漫性细支气管炎、原发性肺癌、胸膜疾病等中显示降低。（E-I）/I（+）与肺灌注相关（n = 49，r = 0.51，p < 0.001），但不少病例存在不匹配情况，这在原发性肺癌、胸膜疾病、肺气肿、弥漫性细支气管炎等中可见。（E-I）/I（+）与使用81mKr或133Xe通气闪烁图进行的肺通气的相关性（n = 49，r = 0.61，p < 0.001）优于与肺灌注的相关性。通气肺运动成像可显示肺内区域和肺边缘的运动，似乎有助于评估灌注区域的肺通气以及肺灌注。
