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转移性脊柱疾病的治疗管理。

Management of metastatic spine disease.

机构信息

H. Lee Moffitt Cancer Center & Research Institute, NeuroOncology Program and Department of Neurosurgery, University of South Florida College of Medicine, Tampa, Florida 33612, USA.

出版信息

Curr Opin Support Palliat Care. 2010 Sep;4(3):182-8. doi: 10.1097/SPC.0b013e32833d2fdd.

Abstract

PURPOSE OF REVIEW

In metastatic spine disease, technologic advancements, neurologic recovery, pain relief, cost-effectiveness, and health-related quality of life have all strengthened surgery's and radiation's role in its management.We evaluated different surgical approaches to the spine and the multimodality treatment in the management of these cases.

RECENT FINDINGS

Recently, the survival rate of malignant spinal metastases has rapidly improved because of early detection and multimodality treatment. The goals of surgical intervention are to prolong survival and improve the quality of life of patients.The recent evolution of imaging, radiosurgery, advanced surgical decompressive techniques and instrumentation, as well as percutaneous vertebral body cement augmentation, needs to be considered in the decision-making to optimize patient outcomes.

SUMMARY

Management of patients with spine tumors requires a multidisciplinary team that includes a medical and radiation oncologist and a spine surgeon. Newer surgical techniques that address both tumor resection and spinal stabilization offer the best outcome in selected patients. The prognostic parameters suggested for metastatic spine tumors include the general condition of the patient, neurological status number of spinal and extraspinal metastases, primary site of the cancer, visceral metastasis, and severity of spinal cord compression.

摘要

目的综述

在转移性脊柱疾病中,技术进步、神经恢复、疼痛缓解、成本效益和健康相关生活质量都增强了手术和放疗在其治疗中的作用。我们评估了脊柱的不同手术入路和这些病例的多模态治疗。

最近发现

由于早期发现和多模态治疗,恶性脊柱转移的生存率迅速提高。手术干预的目标是延长患者的生存时间并提高其生活质量。影像学、放射外科、先进的手术减压技术和器械以及经皮椎体骨水泥强化的最新发展,需要在决策中考虑,以优化患者的治疗效果。

总结

脊柱肿瘤患者的管理需要一个多学科团队,包括内科和放射肿瘤学家以及脊柱外科医生。针对肿瘤切除和脊柱稳定的新技术为选定的患者提供了最佳的治疗效果。转移性脊柱肿瘤的预后参数包括患者的一般状况、神经状态、脊柱和脊柱外转移的数量、癌症的原发部位、内脏转移和脊髓压迫的严重程度。

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