Timlin M, Thalgott J, Ameriks J, Jordan F, Kabins M, Gardner V, Fritts K
Royal College of Surgeons in Ireland, Dublin.
Am Surg. 1995 Aug;61(8):704-8.
Frequency of metastasis to the spine in the population of patients suffering from malignant disease is a significant clinical problem, as these patients present with intractable pain and neurologic impairment. The sequelae of metastatic tumors to the spinal column significantly decrease the quality of the patient's life. With the advent of modern chemotherapeutic regimens in metastatic disease, patients with metastatic tumors are living longer and more productive lives. The goal of surgical management of this problem is to increase the quality of the patient's life, and not longevity. The immediate technical goals are resection of the pathological segment, restoration of load bearing capacity for mobilization of the patient, and decompression of compromised neural structures, as well as maintenance of spinal stability to decrease pain and increase the patient's quality of life during the terminal stages. This is a series of 28 patients with metastatic tumors to the spine, with an average age of 61.5 years, ranging from 25-81 years of age. Within this population there were 11 different tumor types. The postoperative survivorship was an average of 6.4 months. Twenty patients in this series had an anterior procedure alone using a combination of Methylmethacrylate and inexpensive plate fixation. Six patients required an anterior/posterior procedure for circumferential spinal compression and instability. These techniques provide immediate spinal stability for rapid mobilization of the patient. Twenty-four patients in the series had significant pain relief, and 17 experienced neurologic improvement.(ABSTRACT TRUNCATED AT 250 WORDS)
恶性疾病患者中脊柱转移的发生率是一个重大临床问题,因为这些患者会出现顽固性疼痛和神经功能损害。脊柱转移性肿瘤的后遗症会显著降低患者的生活质量。随着现代转移性疾病化疗方案的出现,患有转移性肿瘤的患者寿命延长且生活更有意义。该问题手术治疗的目标是提高患者的生活质量,而非延长寿命。直接的技术目标是切除病变节段、恢复患者活动时的承重能力、解除受压神经结构的压迫,以及维持脊柱稳定性以减轻疼痛并在疾病末期提高患者的生活质量。这是一组28例脊柱转移性肿瘤患者,平均年龄61.5岁,年龄范围在25至81岁之间。该组患者中有11种不同的肿瘤类型。术后平均生存期为6.4个月。该组中有20例患者仅采用甲基丙烯酸甲酯和廉价钢板固定联合的前路手术。6例患者因脊柱环形受压和不稳定需要进行前后路联合手术。这些技术可为患者快速活动提供即时的脊柱稳定性。该组中有24例患者疼痛明显缓解,17例神经功能得到改善。(摘要截选至250字)