非人类灵长类动物调节性 T 细胞：当前生物学及其在移植中的意义。
Non-human primate regulatory T cells: current biology and implications for transplantation.
出版信息
Transplantation. 2010 Oct 27;90(8):811-6. doi: 10.1097/TP.0b013e3181ebf782.
Abstract
Regulatory T cells (Treg) offer potential for improving long-term outcomes in cell and organ transplantation. The non-human primate model is a valuable resource for addressing issues concerning the transfer of Treg therapy to the clinic. Herein, we discuss the properties of non-human primate Treg and prospects for their evaluation in allotransplantation and xenotransplantation.
摘要
调节性 T 细胞（Treg）为改善细胞和器官移植的长期预后提供了潜力。非人类灵长类动物模型是解决将 Treg 治疗方法转移到临床应用中所涉及问题的宝贵资源。本文讨论了非人类灵长类 Treg 的特性及其在同种异体移植和异种移植中的评估前景。
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本文引用的文献
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Investigation of lymphocyte depletion and repopulation using alemtuzumab (Campath-1H) in cynomolgus monkeys.使用阿仑单抗（Campath-1H）在食蟹猴中进行淋巴细胞耗竭和重建的研究。
Am J Transplant. 2010 Apr;10(4):773-783. doi: 10.1111/j.1600-6143.2010.03050.x.
2
Bortezomib can suppress activation of rapamycin-resistant memory T cells without affecting regulatory T-cell viability in non-human primates.硼替佐米可抑制雷帕霉素耐药记忆 T 细胞的激活，而不影响非人类灵长类动物调节性 T 细胞的活力。
Transplantation. 2009 Dec 27;88(12):1349-59. doi: 10.1097/TP.0b013e3181bd7b3a.
3
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Transplantation. 2009 Nov 15;88(9):1057-64. doi: 10.1097/TP.0b013e3181ba6b1f.
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J Immunol. 2009 Sep 15;183(6):4119-26. doi: 10.4049/jimmunol.0901065. Epub 2009 Aug 28.
6
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8
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