Moreni Sue L, Mitchell Caroline M, Garcia Rochelle L, Eckert Linda O
Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195-6460, USA.
Obstet Gynecol Int. 2010;2010:743097. doi: 10.1155/2010/743097. Epub 2010 Jun 29.
Objective. When pathologic discrepancy arises between high-grade cytology on Papanicolaou (Pap) smear and low-grade histology on cervical biopsy, Loop Electrosurgical Excisional Procedure (LEEP) is one management alternative. Our objective was to determine whether the time from initial HGSIL Pap to LEEP affects the pathologic grade of the LEEP specimen. Study Design. We performed a retrospective case-control study identifying LEEPs performed for discrepancy over a 10-year period (1997-2007). 121 subjects were separated into two groups based on LEEP pathology (</=CIN 1 and CIN 2,3) and compared using chi(2). Results. Of the 121 LEEP specimens, 67 (55.4%) had CIN 2,3. CIN 2,3 was more often discovered when LEEP was performed within 3 months of the HGSIL Pap smear versus after 5 months (55.2% versus 16.4%, P = .096). Conclusion. Women undergoing LEEP for discrepancy >5 months from their HGSIL Pap demonstrated a trend toward less CIN 2,3 on LEEP pathology.
目的。当巴氏涂片（Pap）的高级别细胞学检查结果与宫颈活检的低级别组织学检查结果出现病理差异时，环形电切术（LEEP）是一种治疗选择。我们的目的是确定从最初的高度鳞状上皮内病变（HGSIL）巴氏涂片到进行LEEP的时间是否会影响LEEP标本的病理分级。研究设计。我们进行了一项回顾性病例对照研究，确定了在10年期间（1997 - 2007年）因差异而进行的LEEP手术。根据LEEP病理结果（≤CIN 1和CIN 2、3）将121名受试者分为两组，并使用卡方检验进行比较。结果。在121例LEEP标本中，67例（55.4%）为CIN 2、3。与在HGSIL巴氏涂片后5个月后进行LEEP相比，在HGSIL巴氏涂片后3个月内进行LEEP时更常发现CIN 2、3（55.2%对16.4%，P = 0.096）。结论。从HGSIL巴氏涂片后超过5个月因差异而接受LEEP的女性，其LEEP病理结果显示CIN 2、3的趋势较低。
