高对映选择性的双环亚胺氢解去对称化反应，得到多官能化的手性环状化合物。
Highly enantioselective hydrogenative desymmetrization of bicyclic imides leading to multiply functionalized chiral cyclic compounds.
机构信息
Department of Applied Chemistry, Graduate School of Science and Engineering, Tokyo Institute of Technology, 2-12-1 O-okayama, Meguro-ku, Tokyo 152-8552, Japan.
出版信息
J Am Chem Soc. 2010 Aug 25;132(33):11414-5. doi: 10.1021/ja105048c.
PMID:20672811
Abstract
Highly enantioselective hydrogenative desymmetrization of bicyclic imides has been developed with chiral Cp*Ru(PN) catalysts. The present hydrogenation directly provides stereochemically well-defined cyclic compounds with excellent enantiomeric exessses, which might otherwise require a detour to reach.
摘要
手性 Cp*Ru(PN)催化剂实现了双环亚胺的高对映选择性氢化去对称化。该氢化反应可直接立体选择性地构建具有优异对映过量的环状化合物，而无需迂回构建。
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