Institute of Biotechnology, University of Cambridge, Tennis Court Road, Cambridge, Cambridgeshire, United Kingdom.
Antioxid Redox Signal. 2011 Oct 1;15(7):2067-79. doi: 10.1089/ars.2010.3459. Epub 2010 Dec 2.
Schizophrenia is a psychiatric illness that affects approximately 30 million people worldwide. Converging lines of evidence suggest that mitochondrial function may be compromised in this disorder, and this can lead to perturbations in calcium buffering, oxidative phosphorylation, increased production of reactive oxygen species, and apoptotic factors, which can, in turn, affect neuronal processes such as neurotransmitter synthesis and synaptic plasticity. Proteomics studies in brain and peripheral tissues of schizophrenia patients have provided considerable evidence and identified biomarker fingerprints corresponding to such pathways. Here we review the results of these studies with a focus on the biomarker pattern depicting alterations in energy metabolism and oxidative stress in this debilitating illness.
精神分裂症是一种影响全球约 3000 万人的精神疾病。越来越多的证据表明，线粒体功能可能在这种疾病中受到损害，这可能导致钙缓冲、氧化磷酸化、活性氧产生增加和凋亡因子的紊乱，进而影响神经元过程，如神经递质合成和突触可塑性。精神分裂症患者的大脑和外周组织的蛋白质组学研究提供了大量证据，并确定了与这些途径相对应的生物标志物特征。本文重点综述了这些研究的结果，描述了在这种使人衰弱的疾病中能量代谢和氧化应激改变的生物标志物模式。
