Department of Molecular Biology, University of Wyoming, Dept. 3944, 1000 E. University Ave., Laramie, WY 82071, USA.
J Bacteriol. 2010 Oct;192(19):5253-6. doi: 10.1128/JB.00736-10. Epub 2010 Jul 30.
The SCHIC domain of the B12-binding domain family present in the Rhodobacter sphaeroides AppA protein binds heme and senses oxygen. Here we show that the predicted SCHIC domain PpaA/AerR regulators also bind heme and respond to oxygen in vitro, despite their low sequence identity with AppA.
类 B12 结合结构域家族的 SCHIC 结构域存在于球形红杆菌 AppA 蛋白中,可结合血红素并感应氧气。在此,我们表明,预测的 SCHIC 结构域 PpaA/AerR 调节剂尽管与 AppA 的序列同一性较低,但也在体外结合血红素并对氧气作出反应。