Ripamonti G, De Medici C, Guzzaloni G, Moreni G, Ardizzi A, Morabito F
Centro Auxologico Italiano di Piancavallo, IRCCS, Milano.
Minerva Med. 1991 Jun;82(6):345-8.
The incidence of impaired glucose tolerance (IGT) in obese juvenile has not yet been well defined. Glycemic and insulin responses to OGTT were evaluated in 398 obese juveniles (and 70 healthy control subjects) to investigate possible correlations with age, body mass index (BMI) and obesity duration. Subjects were subdivided into two groups according to OGTT results: obese with normal glucose tolerance (OB-NGT) and obese with impaired glucose tolerance (OB-IGT). IGT was found in 11% of subjects but no correlations were observed in relation to age, BMI and obesity duration. There was no difference in the glycemic response to OGTT in terms of the biological parameters examined. Insulin plasma levels were twice as high in OB-NGT in comparison to control subjects and OB-NGT. Basal insulinemia increased with BMI in OB-IGT but not in OB-NGT.
肥胖青少年糖耐量受损（IGT）的发病率尚未得到明确界定。对398名肥胖青少年（以及70名健康对照受试者）进行了口服葡萄糖耐量试验（OGTT）的血糖和胰岛素反应评估，以研究其与年龄、体重指数（BMI）和肥胖持续时间的可能相关性。根据OGTT结果，受试者被分为两组：糖耐量正常的肥胖者（OB-NGT）和糖耐量受损的肥胖者（OB-IGT）。11%的受试者被发现患有IGT，但未观察到与年龄、BMI和肥胖持续时间的相关性。在所检查的生物学参数方面，对OGTT的血糖反应没有差异。与对照受试者和OB-NGT相比，OB-NGT的胰岛素血浆水平高出两倍。在OB-IGT中，基础胰岛素血症随BMI增加，而在OB-NGT中则不然。
