Falcone T, Billiar R, Morris D
Department of Medicine, Royal Victoria Hospital, Montreal, Quebec, Canada.
Obstet Gynecol. 1991 Aug;78(2):171-6.
Insulin resistance is common in women with the polycystic ovary syndrome. We investigated the relationship between insulin resistance and the serum inhibin concentration in a group of 19 women with polycystic ovary syndrome and eight control subjects at different phases of the menstrual cycle. Insulin resistance was measured by the frequently sampled intravenous glucose tolerance test, and inhibin was measured by a specific radioimmunoassay. Insulin sensitivity (mean +/- SE) was significantly reduced in the polycystic ovary syndrome group compared with controls: reduced insulin sensitivity 46.7 +/- 5.0 min-1/(nmol/mL), normally insulin-sensitive 106.6 +/- 11.7 min-1/(nmol/mL) (P less than .01). The women with polycystic ovary syndrome had inhibin levels (126 +/- 15.2 microLEq/mL) comparable to those found during the early follicular phase of the control group (117 +/- 22.1 microLEq/mL), but significantly lower than late follicular phase (259 +/- 25.6 microLEq/mL) or luteal phase (448 +/- 91.8 microLEq/mL) levels in the control group. No association was found between the degree of insulin resistance and the inhibin concentration, which remained unaltered over a 3-hour period despite maximal stimulation of endogenous insulin secretion. The inhibin concentrations in polycystic ovary syndrome may reflect impaired follicular maturation. Inhibin secretion is not acutely affected by insulin secretion in normal or in hyperandrogenic women.
胰岛素抵抗在多囊卵巢综合征女性中很常见。我们在一组19名多囊卵巢综合征女性和8名处于月经周期不同阶段的对照受试者中研究了胰岛素抵抗与血清抑制素浓度之间的关系。通过频繁采样静脉葡萄糖耐量试验测量胰岛素抵抗，通过特异性放射免疫测定法测量抑制素。与对照组相比，多囊卵巢综合征组的胰岛素敏感性（平均值±标准误）显著降低：胰岛素敏感性降低为46.7±5.0 min-1/（nmol/mL），正常胰岛素敏感为106.6±11.7 min-1/（nmol/mL）（P<0.01）。多囊卵巢综合征女性的抑制素水平（126±15.2 microLEq/mL）与对照组卵泡早期（117±22.1 microLEq/mL）的水平相当，但显著低于对照组卵泡晚期（259±25.6 microLEq/mL）或黄体期（448±91.8 microLEq/mL）的水平。未发现胰岛素抵抗程度与抑制素浓度之间存在关联，尽管内源性胰岛素分泌受到最大刺激，但抑制素浓度在3小时内保持不变。多囊卵巢综合征中的抑制素浓度可能反映卵泡成熟受损。在正常或高雄激素女性中，抑制素分泌不受胰岛素分泌的急性影响。
