Murayama Y, Viñuela F, Suzuki Y, Massoud T F, Guglielmi G, Iwaki M, Kamio M, Abe T
Endovascular Therapy Service and Leo G. Rigler Radiological Research Center, UCLA Medical Center; Los Angeles, CA, USA.
Interv Neuroradiol. 1997 Nov 30;3 Suppl 2:156-61. doi: 10.1177/15910199970030S233. Epub 2001 May 15.
Ion implantation and protein-coatings were utilized to alter the surface properties (endothelial cellular adhesion) and enhance the thrombogenicity of Guglielmi detachable coils (GDCs) for endovascular treatment of cerebral aneurysms. These modified GDCs were compared with standard GDCs in the treatment of experimental swine aneurysms. Standard GDCs and ion-implanted protein coated GDCs were used to treat 32 aneurysms in 16 swine. GDCs were coated with either proteins, collagen (n=5), vitronectin (n=4), fibrinogen (Fn=3), laminin (n=2), or fibronectin (n=2) and underwent Ne(+) or He(+) implantation with a fluence of 1 x 10(14--) 10(15) ions/cm(2) at an energy of 150 keV. Bilateral experimental swine aneurysms were embolized with standard GDCs (n=16) on one side and with ion-implanted proteincoated GDCs (n=16; total) on the other side. The necks of aneurysms were evaluated macroscopically and histopathologically at autopsy using day 14 posttreatment specimens. Greater fibrous coverage of the necks of aneurysms were observed in the ion-implanted coil group. The results of this experimental study indicate that Ion implantation combined with protein coating of GDCs improved cellular adhesion and proliferation. Future application of this technology may provide early wound healing at the necks of embolized widenecked cerebral aneurysms.
离子注入和蛋白质涂层被用于改变表面特性（内皮细胞粘附），并增强 Guglielmi 可脱卸弹簧圈（GDC）的血栓形成性，用于脑动脉瘤的血管内治疗。在实验性猪动脉瘤治疗中，将这些改良的 GDC 与标准 GDC 进行比较。标准 GDC 和离子注入蛋白质涂层 GDC 用于治疗 16 头猪的 32 个动脉瘤。GDC 分别用蛋白质、胶原蛋白（n = 5）、玻连蛋白（n = 4）、纤维蛋白原（Fn = 3）、层粘连蛋白（n = 2）或纤连蛋白（n = 2）进行涂层，并以 150 keV 的能量、1×10¹⁴ - 10¹⁵ 离子/cm² 的注量进行 Ne⁺ 或 He⁺ 注入。双侧实验性猪动脉瘤，一侧用标准 GDC（n = 16）栓塞，另一侧用离子注入蛋白质涂层 GDC（n = 16；共）栓塞。在治疗后第 14 天，使用尸检标本对动脉瘤颈部进行宏观和组织病理学评估。在离子注入弹簧圈组中，观察到动脉瘤颈部有更大的纤维覆盖。这项实验研究的结果表明，GDC 的离子注入结合蛋白质涂层改善了细胞粘附和增殖。这项技术的未来应用可能为栓塞的宽颈脑动脉瘤颈部提供早期伤口愈合。
