Rojas Bilbao Erica A, Nesprias Martina, Pulero Carla, Giménez Liliana, Zerga Marta, Chirife Ana María
Departamento de Patología, Instituto de Oncología Angel H. Roffo, Universidad de Buenos Aires.
Medicina (B Aires). 2010;70(4):333-8.
Clinical, histological features and outcome of a cohort of patients with orbital and adnexal lymphoproliferative tumors were evaluated. Twenty-five cases in an oncologic referral center from 1995 to 2008, were included in the study. Each case had detailed immunophenotypic analysis using a panel of monoclonal antibodies (CD45, CD20, CD3, CD5, CD23, BCL2, BCL6, BCL10, Ki67, CD30, CD15, BCL1, Kappa, Lambda, CD138). Lesions were classified by using WHO (2008) lymphomas classification. Twenty-three patients were found to have primary and two secondary lymphomas. Histological subtypes were: 16 patients with marginal zone B cell lymphoma of mucosa-associated lymphoid tissue (MALT) lymphoma, four diffuse large B cell lymphomas, two mantle cell lymphomas, two follicular lymphomas, and one Hodgkin lymphoma. Among the 25 patients studied, 22 had localized stage. Extranodal marginal zone lymphoma was the most frequent type of primary orbital and adnexal lymphoma. In this study localized disease was observed in most cases, and distant spread of the lymphomas was infrequent.
对一组眼眶及附属器淋巴增殖性肿瘤患者的临床、组织学特征及预后进行了评估。本研究纳入了1995年至2008年在一家肿瘤转诊中心的25例病例。每例病例均使用一组单克隆抗体（CD45、CD20、CD3、CD5、CD23、BCL2、BCL6、BCL10、Ki67、CD30、CD15、BCL1、κ、λ、CD138）进行了详细的免疫表型分析。病变采用世界卫生组织（2008年）淋巴瘤分类法进行分类。发现23例患者患有原发性淋巴瘤，2例患有继发性淋巴瘤。组织学亚型为：16例黏膜相关淋巴组织边缘区B细胞淋巴瘤（MALT淋巴瘤）、4例弥漫性大B细胞淋巴瘤、2例套细胞淋巴瘤、2例滤泡性淋巴瘤和1例霍奇金淋巴瘤。在研究的25例患者中，22例为局限性期。结外边缘区淋巴瘤是原发性眼眶及附属器淋巴瘤最常见的类型。在本研究中，大多数病例观察到局限性疾病，淋巴瘤远处转移不常见。
