Department of Radiology, Kaunas University of Medicine, Eiveniu 2, 50009 Kaunas, Lithuania.
Medicina (Kaunas). 2010;46(5):341-4.
Gliomatosis cerebri is a rare diffusely infiltrating glial tumor involving two or more lobes and is frequently is bilateral. Infiltrative extent of tumor is out of proportion to histological and clinical features. We present a case in which finally the diagnosis of gliomatosis cerebri was made. In this case, computed tomography showed that midline structures were insignificantly shifted to the left, there was a mild dilatation of lateral ventricles more expressed on the right, and no pathologic changes of brain tissue density were found. On magnetic resonance tomography, T2W/SE and T2W/FLAIR images revealed zones of hyperintense signal, spreading with time, through several lobes of the brain with no enhancement on T1W images. Diagnosis of gliomatosis cerebri was suspected, stereotaxic biopsy was performed, and pathological examination revealed changes typical of diffuse glial tumor. In this article, changes typical of gliomatosis cerebri seen in other radiological methods such as computed tomography, magnetic resonance spectroscopy, dynamic contrast-enhanced T2*-weighted magnetic resonance, and positron emission tomography also are discussed.
脑胶质瘤病是一种罕见的弥漫性浸润性神经胶质瘤,累及两个或多个脑叶,常为双侧性。肿瘤的浸润范围与组织学和临床特征不成比例。我们报告了一例最终诊断为脑胶质瘤病的病例。在该病例中,计算机断层扫描显示中线结构向左轻度移位,右侧侧脑室轻度扩张,脑组织密度无病理性改变。磁共振成像 T2W/SE 和 T2W/FLAIR 图像显示高信号区域,随着时间的推移通过大脑的几个脑叶扩散,T1W 图像无增强。怀疑脑胶质瘤病,行立体定向活检,病理检查显示弥漫性胶质肿瘤的典型改变。本文还讨论了脑胶质瘤病在其他影像学方法(如计算机断层扫描、磁共振波谱、动态对比增强 T2*-加权磁共振和正电子发射断层扫描)中的典型改变。