Komeno Y, Ako J, Shimada Y, Namba Y, Matsuse T, Toba K, Ouchi Y
Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo.
Nihon Ronen Igakkai Zasshi. 2001 Jul;38(4):540-3. doi: 10.3143/geriatrics.38.540.
Gliomatosis cerebri is a rare form of glioma, which diffusely extends to both cerebral hemispheres. Because it sometimes fails to show severe neurological symptoms in spite of diffuse invasion, the antemortem diagnosis is difficult. We report a case of a 77-year-old woman, who was admitted with progressive left hemiparesis and dysarthralgia. Plain CT scan of the brain showed almost no abnormal findings. MRI T2-weighted image revealed widespread and nearly symmetrical extension of a high intensity area from the corpus callosum to the deep white matter of both cerebral hemispheres. Open biopsy of the brain showed glioblastoma multiforme, which finally confirmed the clinical diagnosis of gliomatosis cerebri. We also review the classic and recent literatures.
大脑胶质瘤病是一种罕见的胶质瘤形式，它会弥漫性地延伸至双侧大脑半球。由于它有时尽管有弥漫性浸润却未表现出严重的神经症状，所以生前诊断较为困难。我们报告一例77岁女性病例，该患者因进行性左侧偏瘫和构音障碍入院。脑部平扫CT几乎未显示异常结果。MRI T2加权像显示从胼胝体到双侧大脑半球深部白质有广泛且近乎对称的高强度区域延伸。脑部开放活检显示多形性胶质母细胞瘤，最终确诊为大脑胶质瘤病。我们还回顾了经典及近期文献。
