Yeh I T, LiVolsi V A, Noumoff J S
Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia.
Pathol Res Pract. 1991 Mar;187(2-3):129-44. doi: 10.1016/S0344-0338(11)80763-6.
The past two decades have seen an increase in the incidence of endocervical carcinoma. Numerous studies have increased understanding of these tumors; hormonal therapy, human papilloma virus, and other cofactors have been implicated in the etiology of endocervical carcinoma. Early diagnosis is difficult: precursor lesions to adenocarcinoma in situ are still poorly defined and understood, and there may be a rapid transit time from in situ to invasive carcinoma. The definition of microinvasive adenocarcinoma is not uniformly agreed upon, and at this time the recommendation is not to use the term. Histologic typing and grading of adenocarcinoma may be useful in the prediction of prognosis for patients. Therapy is based upon stage of disease, the most beneficial results being obtained from either radical surgery or combination surgery and radiation therapy.
在过去二十年中，宫颈内膜癌的发病率有所上升。众多研究增进了人们对这些肿瘤的了解；激素疗法、人乳头瘤病毒及其他辅助因素被认为与宫颈内膜癌的病因有关。早期诊断困难：原位腺癌的前驱病变仍定义不清且了解不足，而且从原位癌到浸润癌的转变可能很快。微浸润性腺癌的定义尚未达成统一共识，目前的建议是不要使用该术语。腺癌的组织学分类和分级可能有助于预测患者的预后。治疗基于疾病分期，根治性手术或手术与放疗联合使用可取得最有益的效果。
