Department of Medicine, King Saud University, P.O. Box 2925, Riyadh, 11321, Saudi Arabia.
Mod Rheumatol. 2011 Feb;21(1):73-5. doi: 10.1007/s10165-010-0340-4. Epub 2010 Aug 4.
Systemic lupus erythematosus (SLE) is one of the common autoimmune disorders that affect women during their childbearing years. Disease activity frequently increases during pregnancy and the postpartum period, representing a challenge for both the patient and the treating physician(s). We report a case of successful management of lupus nephritis flare in the first trimester. The patient developed bilateral leg edema and nephrotic-range proteinuria of 5 g/day. She was treated with steroids and tacrolimus, which resulted in the induction of remission during pregnancy. The patient reached full-term with no maternal or fetal complications. This case indicates that tacrolimus, which is convenient to use and has limited adverse effects, may represent a potential safe and effective treatment option for SLE nephritis during pregnancy.
系统性红斑狼疮（SLE）是一种常见的自身免疫性疾病，常在育龄期女性中发病。疾病活动度常在妊娠期及产褥期增加，给患者和治疗医生带来挑战。我们报告了一例狼疮肾炎在妊娠早期成功治疗的病例。患者出现双侧下肢水肿和 5g/天的肾病范围蛋白尿。她接受了激素和他克莫司治疗，在妊娠期间诱导缓解。患者足月分娩，母婴均无并发症。该病例表明，使用方便且不良反应有限的他克莫司可能是妊娠期狼疮肾炎的一种潜在安全有效的治疗选择。
