Schiavone A, Brambilla A
Department of Pharmacology, Istituto De Angeli, Milano, Italy.
Pharmacol Res. 1991 Apr;23(3):233-9. doi: 10.1016/s1043-6618(05)80082-9.
We investigated a series of muscarinic antagonists for their ability to inhibit muscarinic-mediated secretions from salivary and sweat glands in the rat. Their potency in blocking saliva secretion was compatible with the inhibition of M3 receptors. A highly significant correlation was found between their potency in blocking secretion from both salivary and sweat glands. These results indicate that salivary and sweat glands possess the same muscarinic receptors which conform to the M3 subtype.
我们研究了一系列毒蕈碱拮抗剂抑制大鼠唾液腺和汗腺毒蕈碱介导分泌的能力。它们阻断唾液分泌的效力与对M3受体的抑制作用相符。在它们阻断唾液腺和汗腺分泌的效力之间发现了高度显著的相关性。这些结果表明，唾液腺和汗腺拥有相同的毒蕈碱受体，且这些受体符合M3亚型。
