基质辅助激光解吸电离质谱成像在药物研究中的应用。
Applications of MALDI-MSI to pharmaceutical research.
作者信息
Prideaux Brendan, Staab Dieter, Stoeckli Markus
机构信息
Analytical Sciences, Novartis Institutes for BioMedical Research, Basel, Switzerland.
出版信息
Methods Mol Biol. 2010;656:405-13. doi: 10.1007/978-1-60761-746-4_23.
MALDI-MSI has been demonstrated to be a suitable technique in pharmaceutical research for providing information of the distribution of low molecular weight compounds such as drugs and their metabolites within whole-body tissue sections. Important ADME information can be determined by MALDI-MSI analysis of the distribution of drugs and metabolites in whole-body tissue sections taken from animals killed at a range of time points postdose. In this example we applied MALDI-MSI to the localization of a compound and its primary metabolite in whole-body mouse sections.
基质辅助激光解吸电离质谱成像（MALDI-MSI）已被证明是药物研究中的一种合适技术，可用于提供低分子量化合物（如药物及其代谢物）在全身组织切片中的分布信息。重要的药物代谢动力学/药物代谢/药物排泄（ADME）信息可通过对在给药后一系列时间点处死的动物所取全身组织切片中的药物和代谢物分布进行MALDI-MSI分析来确定。在本示例中，我们将MALDI-MSI应用于在全身小鼠切片中定位一种化合物及其主要代谢物。
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