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采用析因法制备蜡质氧苯酮微粒子。

Formulation of wax oxybenzone microparticles using a factorial approach.

机构信息

Faculty of Pharmacy, Department of Pharmaceutics, Alexandria University, Khartoum square, Azarita, Alexandria 21521, Egypt.

出版信息

J Microencapsul. 2010;27(7):628-39. doi: 10.3109/02652048.2010.506580.

Abstract

Oxybenzone wax microparticles (MPs) were prepared by the hydrophobic congealable disperse phase method. The formulation of oxybenzone-loaded MPs was optimized using a 2⁴ experimental design. Factorial analysis indicated that the main MP characteristics were influenced by initial drug loading, emulsification speed, emulsifier concentration and hydrophilic-lipophilic balance. MPs were spherical with 50.5–88.1 μm size range, 17.8–38.9 drug content in mg/100 mg MPs and 33.1–87.2% oxybenzone release in 1 h. A wide range of sunscreen delivery systems suitable for different formulation purposes were generated which may contribute to the advanced formulation of sunscreen products with improved performance.

摘要

氧苯酮蜡质微球(MPs)采用疏水性凝聚分散相法制备。采用 2⁴ 实验设计优化了载氧苯酮 MPs 的配方。析因分析表明,主要 MPs 特性受初始药物载量、乳化速度、乳化剂浓度和亲水-亲脂平衡的影响。MPs 呈球形,粒径为 50.5-88.1 μm,药物含量为 17.8-38.9 mg/100 mg MPs,1 h 内释放氧苯酮 33.1-87.2%。生成了一系列适用于不同配方目的的防晒输送系统,这可能有助于提高性能的防晒产品的高级配方。

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