Pharmaceutics Research Projects Laboratory, Department of Pharmaceutical Sciences, Dr Hari Singh Gour Vishwavidyalaya, Sagar, India.
J Microencapsul. 2010 May;27(3):226-33. doi: 10.1080/02652040903067844.
In the present project, Solid Lipid Nanoparticles (SLNs) bearing oxybenzone were prepared by ethanol injection method to improve its effectiveness as sunscreen. SLNs were characterized for particle size,polydispersity index, zeta potential and surface morphology. The optimized SLNs bearing oxybenzone were incorporated into water-removable cream base and compared with SLNs unloaded water-removable cream base for in vitro and in vivo parameters. Cream base formulation containing SLNs (Csd) with 5% oxybenzone showed slow drug release and better sun protecting factor (more than 25) compared to cream base containing 5% oxybenzone. Confocal Laser Scanning Microscopy was used to visualize the distribution of developed formulations in skin. CLSM indicated prolonged retention of SLNs in the stratum corneum as compared to plain cream base. These studies revealed that the cream base bearing SLNs exhibited good skin retention as well as enhanced sun protection effect compared to cream base.
在本项目中，通过乙醇注入法制备了载有氧苯酮的固体脂质纳米粒（SLNs），以提高其作为防晒霜的功效。对 SLNs 的粒径、多分散指数、Zeta 电位和表面形态进行了表征。将优化的载有氧苯酮的 SLNs 掺入可水洗乳膏基质中，并与未载药的 SLNs 可水洗乳膏基质进行体外和体内参数比较。含有 5%氧苯酮的载有 SLNs（Csd）的乳膏基质制剂显示出比含有 5%氧苯酮的乳膏基质制剂更慢的药物释放和更好的防晒因子（超过 25）。共聚焦激光扫描显微镜用于可视化开发制剂在皮肤中的分布。CLSM 表明，与普通乳膏基质相比，SLNs 在角质层中的保留时间更长。这些研究表明，与乳膏基质相比，载有 SLNs 的乳膏基质表现出良好的皮肤滞留性和增强的防晒效果。
