Department of Biochemistry and Medical Genetics, School of Health Care, Medical University of Silesia, Katowice, Poland.
Pediatr Neurol. 2010 Jul;43(1):25-8. doi: 10.1016/j.pediatrneurol.2010.02.016.
Ischemic stroke in children is relatively rare, but it remains an important medical problem. Previous studies on Polish children have implicated dyslipidemias as significant risk factors in stroke. To search for genetic factors associated with the disease, the possible association between apolipoprotein E gene epsilon polymorphism and childhood stroke was evaluated. The study population consisted of 243 individuals: 72 children with ischemic stroke and 100 of their biological parents and 71 children without any symptoms of stroke. The apolipoprotein E gene epsilon polymorphism was genotyped using restriction fragment length polymorphism methodology. To analyze the possible association between this polymorphism and stroke, the transmission disequilibrium test and the case-control model were used. No preferential distribution of any allele from parents to the affected children was observed. There were also no significant differences in genotype and allele distribution between patients and control subjects. Study findings did not confirm that epsilon polymorphism of the apolipoprotein E gene is a risk factor of ischemic stroke in children.
儿童缺血性脑卒中相对少见，但仍是一个重要的医学问题。先前针对波兰儿童的研究提示血脂异常是脑卒中的重要危险因素。为了寻找与疾病相关的遗传因素，评估了载脂蛋白 E 基因 ε 多态性与儿童脑卒中的可能相关性。研究人群包括 243 个人：72 例缺血性脑卒中患儿及其 100 名生物学父母和 71 例无任何脑卒中症状的儿童。采用限制性片段长度多态性方法对载脂蛋白 E 基因 ε 多态性进行基因分型。为了分析该多态性与脑卒中之间的可能相关性，使用传递不平衡检验和病例对照模型。未观察到从父母到患病儿童的任何等位基因的优先分布。患者和对照组之间在基因型和等位基因分布上也没有显著差异。研究结果并未证实载脂蛋白 E 基因 ε 多态性是儿童缺血性脑卒中的危险因素。
