干细胞和祖细胞中的 DNA 损伤反应差异。
Differential DNA damage response in stem and progenitor cells.
机构信息
Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
出版信息
Cell Stem Cell. 2010 Aug 6;7(2):145-7. doi: 10.1016/j.stem.2010.07.006.
PMID:20682442
Abstract
The long lifespan of tissue-specific stem cells suggests that they may respond differently to DNA damage than downstream cells. In this issue of Cell Stem Cell, two groups address this hypothesis by examining DNA damage responses in hematopoietic stem and progenitor cells (Milyavsky et al., 2010; Mohrin et al., 2010).
摘要
组织特异性干细胞的长寿命表明，它们对 DNA 损伤的反应可能与下游细胞不同。在本期《细胞-干细胞》杂志上，两组研究人员通过研究造血干细胞和祖细胞中的 DNA 损伤反应（Milyavsky 等人，2010；Mohrin 等人，2010）来验证这一假说。
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