可溶性碳酸酐酶 IX 不是人类肾细胞癌的独立预后因素。
Soluble carbonic anhydrase IX is not an independent prognostic factor in human renal cell carcinoma.
机构信息
Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.
出版信息
Anticancer Res. 2010 Jul;30(7):2953-7.
UNLABELLED
The aim of this study was to evaluate the prognostic information of soluble carbonic anhydrase (CA) IX expression in renal cell carcinoma (RCC).
PATIENTS AND METHODS
Serum CA IX was analysed in 361 patients. Tumour type, TNM stage, nuclear grade, and RCC-specific survival were assessed. Serum and immunohistochemical expression were compared.
RESULTS
Median serum CA IX expression was 141 (range 2-4, 181) pg/ml. Levels were significantly higher in 287 patients with clear cell, compared to 40 papillary (p<0.001) and 22 oncocytoma (p=0.002), but not to 12 chromophobe RCC (p=0.35). Serum CA IX in clear cell RCC was positively correlated to TNM stage (p=0.002). There was a positive trend between serum and immunohistochemical CA IX expression. In a multivariate analysis of clear cell RCC, TNM stage and nuclear grade were independent prognostic factors.
CONCLUSION
Serum CA IX was higher in clear cell RCC compared to other RCC types. In clear cell RCC, serum CA IX correlated to TNM stage, but not survival.
目的
本研究旨在评估可溶性碳酸酐酶（CA）IX 在肾细胞癌（RCC）中的预后信息。
方法
对 361 例患者的血清 CAIX 进行分析。评估肿瘤类型、TNM 分期、核分级和 RCC 特异性生存情况。比较血清和免疫组织化学表达。
结果
中位血清 CAIX 表达为 141（范围 2-4, 181）pg/ml。与 40 例乳头状（p<0.001）和 22 例嗜酸细胞瘤（p=0.002）相比，287 例透明细胞 RCC 患者的水平明显更高，但与 12 例嫌色细胞 RCC 相比无显著差异（p=0.35）。透明细胞 RCC 患者血清 CAIX 与 TNM 分期呈正相关（p=0.002）。血清和免疫组织化学 CAIX 表达之间存在正相关趋势。在透明细胞 RCC 的多因素分析中，TNM 分期和核分级是独立的预后因素。
结论
与其他 RCC 类型相比，透明细胞 RCC 患者血清 CAIX 水平更高。在透明细胞 RCC 中，血清 CAIX 与 TNM 分期相关，但与生存无关。
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