Department of Surgery, Gastroenterological Center, Yokohama City University/4-57 Urafune-cho, Minami-ku, Yokohama 232-0024, Japan.
Anticancer Res. 2010 Jul;30(7):3063-9.
The prognosis for patients with N0 oesophageal cancer is favourable, but relevant prognostic factors and appropriate surveillance protocols have not been identified for these patients.
A total of 210 oesophageal cancer patients were included in this study. Of these, 92 (43.8%) had no lymph node metastasis. Predictive factors for lymph node metastasis were evaluated in N0 oesophageal cancer. Survival, prognostic factors, causes of death and pattern of recurrence were assessed between patients with and without lymph node metastasis.
Logistic regression analysis revealed that depth of tumour invasion (T1) was an independent predictive factor for N0. The Cox proportional hazard regression model showed that venous invasion was an independent prognostic factor for disease-specific survival in N0 oesophageal cancer patients (hazard ratio=3.977, p=0.042). Locoregional recurrence was less frequent in patients with N0 oesophageal cancer (p=0.0319).
Meticulous and long-term follow-up is necessary even for patients with N0 oesophageal cancer, particularly for those with adverse prognostic factors.
N0 期食管癌患者的预后良好，但这些患者的相关预后因素和适当的监测方案尚未确定。
本研究共纳入 210 例食管癌患者，其中 92 例（43.8%）无淋巴结转移。评估 N0 期食管癌患者的淋巴结转移预测因素。评估有和无淋巴结转移的患者之间的生存、预后因素、死亡原因和复发模式。
Logistic 回归分析显示肿瘤浸润深度（T1）是 N0 的独立预测因素。Cox 比例风险回归模型显示静脉侵犯是 N0 期食管癌患者疾病特异性生存的独立预后因素（风险比=3.977，p=0.042）。N0 期食管癌患者局部区域复发较少（p=0.0319）。
即使对于 N0 期食管癌患者，也需要进行细致和长期的随访，特别是对于具有不良预后因素的患者。
