University of Padua, School of Medicine, Department of Surgical & Gastroenterological Sciences, Via Giustiniani 2, 35128 Padova, Italy.
Anticancer Res. 2010 Jul;30(7):3083-6.
The aim of this study was to evaluate the usefulness of fine-needle aspiration cytology (FNAC) and (99m)Tc-pertechnetate scintigraphy (TS) together in patients with differentiated thyroid carcinoma. Data from a series of 357 patients (284 women and 73 men, median age 43 years, range 19-73) with solitary thyroid nodule and no signs of hyperfunction, who had undergone both FNAC and TS prior to surgery, were retrospectively reviewed. FNAC distinguished 3 groups of TN (benign, follicular neoplasm, cancer), while patients with 'cold' TN were considered at risk of having a thyroid tumor. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were: 95%, 21%, 20%, 95% and 34% for TS; 82%, 99%, 96%, 96% and 96% for FNAC; 98%, 99%, 97%, 98%, and 99% for TS and FNAC together, respectively. In conclusion, patients with 'cold' TN and FNAC suggesting follicular neoplasm should be considered at risk of having cancer.
本研究旨在评估细针穿刺细胞学（FNAC）和（99m）Tc-过锝酸盐闪烁扫描（TS）联合应用于分化型甲状腺癌患者的价值。对 357 例因单发甲状腺结节且无功能亢进迹象而行 FNAC 和 TS 检查、并在术前接受这两种检查的患者的资料进行回顾性分析。FNAC 将 TN 分为 3 组（良性、滤泡性肿瘤、癌），而“冷”结节的患者被认为有甲状腺肿瘤的风险。TS 的敏感性、特异性、阳性预测值、阴性预测值和准确性分别为：95%、21%、20%、95%和 34%；FNAC 为 82%、99%、96%、96%和 96%；TS 和 FNAC 联合应用时分别为 98%、99%、97%、98%和 99%。总之，“冷”结节且 FNAC 提示滤泡性肿瘤的患者应被认为有患癌的风险。
