Vogel F S
Natl Cancer Inst Monogr. 1977 Dec;46:51-6.
Gliomas, derived from astrocytes, oligodendroglia, or ependyma, are each united into a continuum by a graduation of anaplasia. Neoplasms originate at all levels of each continuum; subsequently, some move along its declivity. Conversely, neuroblastic tumors may differentiate, whereas concomitantly in the same lesion, the glial stroma may dedifferentiate. Anaplastic glia, as in a glioblastoma multiforme, can initiate malignant transformation in alien cells.
胶质瘤起源于星形胶质细胞、少突胶质细胞或室管膜细胞，每种胶质瘤都通过间变程度形成一个连续统一体。肿瘤在每个连续统一体的各个水平发生；随后，一些肿瘤沿着其斜坡发展。相反，神经母细胞瘤可能会分化，而在同一病变中，神经胶质基质可能会同时发生去分化。间变性胶质细胞，如多形性胶质母细胞瘤中的间变性胶质细胞，可引发异源性细胞的恶性转化。
