Mortel Marie Rosalette, Emer Jason
University of the Philippines College of Medicine, Manila, Philippines.
J Drugs Dermatol. 2010 Aug;9(8):947-58.
Psoriasis and psoriatic arthritis are immune-mediated, chronic, inflammatory diseases that place a heavy burden on the lifestyle of patients affected. Current understanding of the pathophysiology of these conditions has produced very encouraging new medical developments, largely a consequence of research that has targeted precise elements of the immune cascade, expanding the repertoire of therapeutic options available to dermatologists. Promising new treatments, such as antibodies to interleukin-12 and -23, show superior efficacy and safety in treating psoriasis; the more sophisticated tumor necrosis factor antagonists significantly improve symptoms of rheumatic and psoriatic arthritis and may also be effective in the treatment of plaque psoriasis. In this article, innovative, new treatments for psoriasis and psoriatic arthritis are critically reviewed.
银屑病和银屑病关节炎是免疫介导的慢性炎症性疾病，给受影响患者的生活方式带来沉重负担。目前对这些病症病理生理学的理解带来了非常令人鼓舞的新医学进展，这在很大程度上是针对免疫级联精确成分进行研究的结果，扩大了皮肤科医生可用的治疗选择范围。有前景的新疗法，如抗白细胞介素-12和-23抗体，在治疗银屑病方面显示出卓越的疗效和安全性；更先进的肿瘤坏死因子拮抗剂能显著改善风湿性和银屑病关节炎的症状，也可能对斑块状银屑病有效。本文对银屑病和银屑病关节炎的创新新疗法进行了批判性综述。
