Pala G, Pignatti P, Gentile E, Caminati M, Perfetti L, Moscato G
Servizio Autonomo di Allergologia e Immunologia Clinica, Fondazione "Salvatore Maugeri", IRCCS, Istituto Scientifico di Pavia, Italia.
G Ital Med Lav Ergon. 2010 Apr-Jun;32(2):145-8.
Nonasthmatic eosinophilic bronchitis (NAEB) is a condition characterized by corticosteroid-responsive chronic cough, sputum eosinophilia and absence of symptoms or objective evidence of variable airflow obstruction and airway hyper-responsiveness. Like asthma, NAEB can be associated with exposure to occupational sensitizers and can be considered as being a variant of occupational asthma when it develops as a consequence of work exposure. Few case reports of NAEB caused by workplace exposure have been reported. Bakers are at high risk of developing occupational respiratory disorders and three cases of occupational NAEB have been described. We describe the first case of occupational NAEB due to storage mites in a baker in which the offending agent was identified by means of the basophil activation test (BAT), a new tool which has never been proposed in diagnostic procedures of occupational respiratory allergy. BAT's results allowed the recognition of the offending agent, that is mandatory for diagnosis.
非哮喘性嗜酸性粒细胞性支气管炎(NAEB)是一种以皮质类固醇反应性慢性咳嗽、痰嗜酸性粒细胞增多以及无可变气流受限和气道高反应性的症状或客观证据为特征的病症。与哮喘一样,NAEB可能与接触职业致敏原有关,当它因工作接触而发生时可被视为职业性哮喘的一种变体。关于工作场所接触引起NAEB的病例报告很少。面包师患职业性呼吸系统疾病的风险很高,已有三例职业性NAEB的病例被描述。我们报告了首例面包师因仓储螨导致的职业性NAEB病例,其中通过嗜碱性粒细胞活化试验(BAT)确定了致病因子,这是一种从未在职业性呼吸道过敏诊断程序中被提及的新工具。BAT的结果有助于识别致病因子,这对诊断至关重要。