Allergy and Immunology Unit, Fondazione "Salvatore Maugeri", Institute of Care and Research, Scientific Institute of Pavia, Italy.
Med Lav. 2012 Jan-Feb;103(1):17-25.
Nonasthmatic eosinophilic bronchitis (NAEB) is an important cause of chronic cough, since it is present in 10-15% of patients referred for specialist investigation. The syndrome is considered a variant of occupational asthma when it develops as a consequence of occupational exposure, hence it should be considered in the spectrum of work-related airway diseases.
The aim of this paper was to update and expand the previous reviews on the clinical and pathophysiological features of NAEB and analyze available data on the occupational causes of the disease. Literature on the topic between the years 1990 and 2010 was reviewed with a Med Line search.
The disease is probably underdiagnosed and an occupational origin was demonstrated only in isolated cases, probably due to the rarity of the disease and the lack of systematic evaluation of bronchial inflammation.
In view of the current knowledge on this condition and the development of techniques to evaluate bronchial inflammation, occupational NAEB cannot be neglected any more and has been rightly included in the spectrum of occupational respiratory disorders.
非哮喘性嗜酸性粒细胞性支气管炎（NAEB）是慢性咳嗽的一个重要病因，因为它存在于 10-15%的被转诊至专科进行检查的患者中。当该综合征由于职业暴露而发展时，被认为是职业性哮喘的一种变异，因此应将其视为与工作相关的气道疾病谱的一部分。
本文旨在更新和扩展之前关于 NAEB 的临床和病理生理学特征的综述，并分析有关该疾病职业病因的现有数据。使用 Med Line 搜索对 1990 年至 2010 年的相关文献进行了回顾。
该疾病可能被漏诊，而且职业性病因仅在个别病例中得到证实，这可能是由于该疾病的罕见性以及对支气管炎症缺乏系统评估所致。
鉴于对该病症的现有认识以及评估支气管炎症的技术的发展，不能再忽视职业性 NAEB，而应将其正确地纳入职业性呼吸障碍谱中。
Zotero 插件