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与含有 0.05%西吡氯铵的漱口液相比,一种精油漱口液的优势:一项为期六个月的研究。

Superiority of an essential oil mouthrinse when compared with a 0.05% cetylpyridinium chloride containing mouthrinse: a six-month study.

机构信息

BIOSCI Canada Ltd, Canada.

出版信息

Int Dent J. 2010 Jun;60(3):175-80.

Abstract

OBJECTIVE

To evaluate the antiplaque/antigingivitis effectiveness of an essential oils containing mouthrinse as compared to a 0.05% cetylpyridinium chloride mouthrinse.

METHOD

Generally healthy subjects with mild to moderate levels of plaque and gingivitis participated in a 6-month, examiner-blind, single centre, randomised, parallel-group controlled clinical trial. They were randomised into three mouthrinse groups--control (C), 0.05% cetylpyridinium chloride (CPC), or a fixed combination of essential oils (EO). Subjects received a dental prophylaxis at baseline and rinsed twice daily in addition to their usual oral hygiene for six months. Plaque Index and Modified Gingival Index were determined at 3 and 6 months.

RESULTS

At 6 months, the EO group exhibited statistically significantly lower mean scores for MGI and PI than CPC (32.4% and 56.2% reductions, respectively). Compared to control, EO provided statistically significantly lower mean MGI and PI scores (36.3% and 69.7 %, respectively). The CPC group showed statistically significantly lower mean MGI and PI scores than the C group (5.8% and 30.7%, respectively).

CONCLUSION

This study demonstrated the superiority of an EO rinse compared to a 0.05% CPC rinse in reducing plaque and gingivitis and confirmed that the daily use of an EO containing mouthrinse can provide a clinically significant benefit in reducing plaque and gingivitis.

摘要

目的

评估一种含精油漱口水相较于 0.05%氯化十六烷基吡啶漱口水的抗菌斑/抗牙龈炎效果。

方法

本为期 6 个月、盲法、单中心、随机、平行组对照临床试验纳入了菌斑和牙龈炎处于轻至中度水平的健康受试者。他们被随机分为三组漱口液组——对照组(C)、0.05%氯化十六烷基吡啶(CPC)或固定混合精油(EO)。受试者在基线时接受了牙齿洁治,并在 6 个月内每天早晚两次漱口,同时保持日常口腔卫生。在 3 个月和 6 个月时分别检测菌斑指数和改良龈炎指数。

结果

在 6 个月时,EO 组的 MGI 和 PI 平均评分明显低于 CPC 组(分别降低 32.4%和 56.2%)。与对照组相比,EO 组的 MGI 和 PI 平均评分明显更低(分别降低 36.3%和 69.7%)。与 C 组相比,CPC 组的 MGI 和 PI 平均评分明显更低(分别降低 5.8%和 30.7%)。

结论

本研究表明,EO 漱口水在减少菌斑和牙龈炎方面优于 0.05% CPC 漱口水,证实了每天使用含 EO 的漱口水可以在减少菌斑和牙龈炎方面提供显著的临床获益。

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