Department of Nuclear Medicine, Cyclotron Research Center, Chonbuk National University Medical School, Jeonju, Jeonbuk 561-712, Korea.
Org Lett. 2010 Sep 3;12(17):3740-3. doi: 10.1021/ol101485n.
Polymer-supported pentaethylene glycols (PSpentaEG) as promising catalysts for nucleophilic fluorination with alkali metal fluoride (MF) could significantly enhance the nucleophilicity of MF and provide simple purification and recycling in the reaction. Furthermore, by their synergistic effect, the combination of PSpentaEG and a tert-alcohol media system showed tremendous efficiency in the fluorination of base-sensitive substrates such as sec-alkyl halide.
聚合物支撑的五乙二醇（PSpentaEG）作为与碱金属氟化物（MF）进行亲核氟化的有前途的催化剂，可以显著提高 MF 的亲核性，并在反应中提供简单的纯化和回收。此外，通过它们的协同效应，PSpentaEG 和叔醇介质系统的组合在氟化基底敏感底物（如仲烷基卤化物）方面表现出了巨大的效率。
