Murdoch Childrens Research Institute, Royal Children's Hospital, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia.
J Infect Dis. 2010 Sep 1;202 Suppl:S43-8. doi: 10.1086/653548.
The successful development and implementation of rotavirus vaccines will have a significant impact on rotavirus-induced gastroenteritis in children worldwide. However, this introduction will increase the immune pressure against wild-type rotavirus strains circulating in the community, altering the forces and balances that drive rotavirus evolution. There is concern that antigenically distinct novel or rare strains may be selected and spread, decreasing vaccine efficacy. This review describes the diversity of rotavirus strains and the mechanism by which wild-type rotavirus strains can evolve, including genetic drift and genetic reassortment.
轮状病毒疫苗的成功开发和应用将对全球儿童轮状病毒肠炎产生重大影响。然而，这种引入将会增加对社区中循环的野生型轮状病毒株的免疫压力，改变驱动轮状病毒进化的力量和平衡。人们担心具有不同抗原性的新型或罕见株可能会被选择和传播，从而降低疫苗的效力。本文综述了轮状病毒株的多样性和野生型轮状病毒株进化的机制，包括遗传漂移和基因重组。
