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首发精神病患者的自杀倾向与洞察力和对精神病的负面信念有关。

Suicidality in first episode psychosis is associated with insight and negative beliefs about psychosis.

机构信息

Department of Mental Health and Addiction, Oslo University Hospital, 0424 Oslo, Norway.

出版信息

Schizophr Res. 2010 Nov;123(2-3):257-62. doi: 10.1016/j.schres.2010.07.018. Epub 2010 Aug 3.

DOI:10.1016/j.schres.2010.07.018
PMID:20685083
Abstract

INTRODUCTION

Suicidal behaviour is prevalent in psychotic disorders. Insight has been found to be associated with increased risk for suicidal behaviour, but not consistently. A possible explanation for this is that insight has different consequences for patients depending on their beliefs about psychosis. The present study investigated whether a relationship between insight, negative beliefs about psychosis and suicidality was mediated by depressive symptoms, and if negative beliefs about psychosis moderated the relationship between insight and suicidality in patients with a first episode of psychosis (FEP).

METHOD

One hundred ninety-four FEP-patients were assessed with a clinical interview for diagnosis, symptoms, functioning, substance use, suicidality, insight, and beliefs about psychosis.

RESULTS

Nearly 46% of the patients were currently suicidal. Depressive symptoms, having a schizophrenia spectrum disorder, insight, and beliefs about negative outcomes for psychosis were independently associated with current suicidality; contradicting a mediating effect of depressive symptoms. Negative beliefs about psychosis did not moderate the effect of insight on current suicidality.

CONCLUSION

The results indicate that more depressive symptoms, higher insight, and negative beliefs about psychosis increase the risk for suicidality in FEP-patients. The findings imply that monitoring insight should be part of assessing the suicide risk in patients with FEP, and that treating depression and counteracting negative beliefs about psychosis may possibly reduce the risk for suicidality.

摘要

简介

自杀行为在精神病患者中很常见。已经发现洞察力与自杀行为风险增加有关,但并非始终如此。对此的一种可能解释是,洞察力对患者的影响因他们对精神病的信念而异。本研究调查了在首发精神病(FEP)患者中,洞察力、对精神病的消极信念与自杀意念之间的关系是否通过抑郁症状来介导,以及对精神病的消极信念是否调节了洞察力与自杀意念之间的关系。

方法

194 名 FEP 患者接受了临床访谈,以评估诊断、症状、功能、物质使用、自杀意念、洞察力和对精神病的信念。

结果

近 46%的患者目前有自杀意念。抑郁症状、患有精神分裂症谱系障碍、洞察力和对精神病负面结果的信念与当前自杀意念独立相关;而抑郁症状并没有起到中介作用。对精神病的消极信念并没有调节洞察力对当前自杀意念的影响。

结论

研究结果表明,更多的抑郁症状、更高的洞察力和对精神病的消极信念增加了 FEP 患者自杀意念的风险。研究结果表明,监测洞察力应该是评估 FEP 患者自杀风险的一部分,而治疗抑郁和对抗对精神病的消极信念可能会降低自杀意念的风险。

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