Department of Hygiene, Medical School, Aristotle University of Thessaloniki, Hippokrateion Hospital, Thessaloniki, Greece.
Int J Gynecol Cancer. 2010 May;20(4):482-7. doi: 10.1111/IGC.0b013e3181d80a8f.
The aim of the present study was to analyze cervical, uterine corpus, and ovarian cancer mortality, between 1980 and 2005, in Greece.
Mortality data and population age distribution were provided by the National Statistical Service of Greece. Time trends of mortality were calculated for each tumor type per 100,000 women in the whole female population of Greece, and 2 different age groups, that is, women aged 49 years and younger and those 50 years and older. Joinpoint regression was used for further analysis of mortality trends.
Overall, cervical and uterine corpus cancer mortality in the whole female population of Greece had a slightly decreasing trend between 1980 and 2005, whereas ovarian cancer mortality rates increased steadily throughout the period studied. Subgroup analyses according to age showed that cervical cancer mortality decreased very slightly only in women older than 50 years, whereas it remained steady in younger women. Uterine corpus cancer mortality decreased slightly in both age groups, but increased during the last years of the study period in the older age group. Ovarian cancer mortality increased in women older than 50 years, whereas it remained steady in the younger age group. Joinpoint regression analysis showed that only the increase after 1997 in the mortality trend for uterine corpus cancer in women 50 years and older was statistically significant (P = 0.0044).
Although our findings regarding cervical cancer mortality in Greece are encouraging, still more efforts are needed, particularly in preventing cervical cancer in younger women. The increasing trend of uterine corpus and ovarian cancer mortality in older women suggests that development of well-organized tertiary centers for the implementation of modern therapeutic modalities is urgently needed.
本研究旨在分析 1980 年至 2005 年期间希腊的宫颈癌、子宫体癌和卵巢癌死亡率。
希腊国家统计局提供了死亡率数据和人口年龄分布。按每 10 万希腊女性总人口和 2 个不同年龄组（49 岁及以下和 50 岁及以上）计算了每种肿瘤类型的死亡率。使用 Joinpoint 回归进一步分析死亡率趋势。
总体而言，希腊女性总人口的宫颈癌和子宫体癌死亡率在 1980 年至 2005 年间呈略有下降趋势，而卵巢癌死亡率在整个研究期间呈稳步上升趋势。根据年龄的亚组分析显示，只有 50 岁以上的女性宫颈癌死亡率略有下降，而年轻女性的死亡率则保持稳定。子宫体癌死亡率在两个年龄组均略有下降，但在老年组的研究后期有所增加。卵巢癌死亡率在 50 岁以上的女性中增加，而在年轻年龄组中保持稳定。Joinpoint 回归分析显示，仅在 1997 年后 50 岁及以上女性子宫体癌死亡率呈上升趋势，具有统计学意义（P=0.0044）。
尽管我们对希腊宫颈癌死亡率的发现令人鼓舞，但仍需要做出更多努力，特别是在预防年轻女性的宫颈癌方面。老年女性子宫体癌和卵巢癌死亡率的上升趋势表明，迫切需要建立组织良好的三级中心，以实施现代治疗模式。
