Chen Ning, Zhou Muke, He Li, Zhou Dong, Li N
Department of Neurology, West China Hospital, Sichuan University, Wai Nan Guo Xue Xiang #37, Chengdu, Sichuan, China, 610041.
Cochrane Database Syst Rev. 2010 Aug 4;2010(8):CD002914. doi: 10.1002/14651858.CD002914.pub5.
Bell's palsy or idiopathic facial palsy is an acute facial paralysis due to inflammation of the facial nerve. A number of studies published in China have suggested acupuncture is beneficial for facial palsy.
The objective of this review was to examine the efficacy of acupuncture in hastening recovery and reducing long-term morbidity from Bell's palsy.
We updated the searches of the Cochrane Neuromuscular Disease Group Trials Specialized Register (24 May 2010), The Cochrane Central Register of Controlled Trials (CENTRAL) (Issue 2, 2010), MEDLINE (January 1966 to May 2010), EMBASE (January 1980 to May 2010), AMED (January 1985 to May 2010), LILACS (from January 1982 to May 2010) and the Chinese Biomedical Retrieval System (January 1978 to May 2010) for randomised controlled trials using 'Bell's palsy' and its synonyms, 'idiopathic facial paralysis' or 'facial palsy' as well as search terms including 'acupuncture'. Chinese journals in which we thought we might find randomised controlled trials relevant to our study were handsearched. We reviewed the bibliographies of the randomised trials and contacted the authors and known experts in the field to identify additional published or unpublished data.
We included all randomised controlled trials involving acupuncture by needle insertion in the treatment of Bell's palsy irrespective of any language restrictions.
Two review authors identified potential articles from the literature search, extracted data and assessed quality of each trial independently. All disagreements were resolved by discussion between the review authors.
The literature search and handsearching identified 49 potentially relevant articles. Of these, six RCTs were included involving 537 participants with Bell's palsy. Two more possible trials were identified in the update than the previous version of this systematic review, but both were excluded because they were not real RCTs. Of the six included trials, five used acupuncture while the other one used acupuncture combined with drugs. No trial reported on the outcomes specified for this review. Harmful side effects were not reported in any of the trials. Poor quality caused by flaws in study design or reporting (including uncertain method of randomisation, allocation concealment and blinding) and clinical differences between trials prevented reliable conclusions about the efficacy of acupuncture.
AUTHORS' CONCLUSIONS: The quality of the included trials was inadequate to allow any conclusion about the efficacy of acupuncture. More research with high quality trials is needed.
贝尔面瘫或特发性面神经麻痹是一种因面神经炎症引起的急性面瘫。中国发表的多项研究表明针灸对面瘫有益。
本综述的目的是研究针灸在加速贝尔面瘫恢复及降低长期发病率方面的疗效。
我们更新了对Cochrane神经肌肉疾病组试验专门注册库(2010年5月24日)、Cochrane对照试验中心注册库(CENTRAL,2010年第2期)、MEDLINE(1966年1月至2010年5月)、EMBASE(1980年1月至2010年5月)、AMED(1985年1月至2010年5月)、LILACS(1982年1月至2010年5月)以及中国生物医学文献数据库(1978年1月至2010年5月)的检索,以查找使用“贝尔面瘫”及其同义词“特发性面神经麻痹”或“面瘫”以及包括“针灸”在内的检索词的随机对照试验。我们对认为可能找到与本研究相关的随机对照试验的中文期刊进行了手工检索。我们查阅了随机试验的参考文献,并联系了该领域的作者和知名专家以识别其他已发表或未发表的数据。
我们纳入了所有通过针刺进行针灸治疗贝尔面瘫的随机对照试验,不受任何语言限制。
两位综述作者从文献检索中识别出潜在文章,独立提取数据并评估每个试验的质量。所有分歧均通过综述作者之间的讨论解决。
文献检索和手工检索共识别出49篇潜在相关文章。其中,纳入了6项随机对照试验,涉及537例贝尔面瘫患者。与本系统综述的上一版本相比,更新过程中又识别出2项可能的试验,但均被排除,因为它们并非真正的随机对照试验。在纳入的6项试验中,5项使用了针灸,另一项使用了针灸联合药物。没有试验报告本综述指定的结局。所有试验均未报告有害副作用。研究设计或报告中的缺陷(包括随机化方法不确定、分配隐藏和盲法)导致的质量较差以及各试验之间的临床差异妨碍了就针灸疗效得出可靠结论。
纳入试验的质量不足以就针灸疗效得出任何结论。需要开展更多高质量试验的研究。