McAllister Kerrie, Walker David, Donnan Peter T, Swan Iain
Department of Otolaryngology, North Glasgow University NHS Trust, Gartnavel General Hospital, Glasgow, UK, G12 0YN.
Cochrane Database Syst Rev. 2011 Feb 16(2):CD007468. doi: 10.1002/14651858.CD007468.pub2.
Bell's palsy is an acute paralysis of one side of the face of unknown aetiology. Bell's palsy should only be used as a diagnosis in the absence of all other pathology. As the proposed pathophysiology is swelling and entrapment of the nerve, some surgeons suggest surgical decompression of the nerve as a possible management option.
The objective of this review was to assess the effectiveness of surgery in the management of Bell's palsy and to compare this to outcomes of medical management.
We searched the Cochrane Neuromuscular Disease Group Specialized Register (23 November 2010). We also searched the Cochrane Central Register of Controlled Trials (CENTRAL) (23 November in The Cochrane Library, Issue 4 2010). We adapted this strategy to search MEDLINE (January 1966 to November 2010) and EMBASE (January 1980 to November 2010).
We included all randomised or quasi-randomised controlled trials involving any surgical intervention for Bell's palsy.
Two review authors independently assessed whether trials identified from the search strategy were eligible for inclusion. Two review authors assessed trial quality and extracted data independently.
Two trials with a total of 69 participants met the inclusion criteria. The first study considered the treatment of 403 patients but only included 44 in their surgical study. These were randomised into a surgical and non surgical group. The second study had 25 participants which they randomly allocated into surgical or control groups.The nerves of all the surgical group participants in both studies were decompressed using a retroauricular approach. The primary outcome was recovery of facial palsy at 12 months. The first study showed that both the operated and non operated groups had comparable facial nerve recovery at nine months. This study did not statistically compare the groups but the scores and size of the groups suggested that statistically significant differences are unlikely. The second study reported no statistically significant differences between their operated and control groups. One operated patient in the first study had 20 dB sensorineural hearing loss and persistent vertigo.
AUTHORS' CONCLUSIONS: There is only very low quality evidence from randomised controlled trials and this is insufficient to decide whether surgical intervention is beneficial or harmful in the management of Bell's palsy.Further research into the role of surgical intervention is unlikely to be performed because spontaneous recovery occurs in most cases.
贝尔面瘫是一侧面部的急性麻痹,病因不明。仅在排除所有其他病变的情况下,才能将贝尔面瘫用作诊断。由于推测的病理生理机制是神经肿胀和受压,一些外科医生建议对神经进行手术减压作为一种可能的治疗选择。
本综述的目的是评估手术治疗贝尔面瘫的有效性,并将其与药物治疗的结果进行比较。
我们检索了Cochrane神经肌肉疾病小组专业注册库(2010年11月23日)。我们还检索了Cochrane对照试验中心注册库(CENTRAL)(2010年第4期《Cochrane图书馆》中的2010年11月23日版本)。我们调整了该策略以检索MEDLINE(1966年1月至2010年11月)和EMBASE(1980年1月至2010年11月)。
我们纳入了所有涉及对贝尔面瘫进行任何手术干预的随机或半随机对照试验。
两位综述作者独立评估从检索策略中识别出的试验是否符合纳入标准。两位综述作者独立评估试验质量并提取数据。
两项共69名参与者的试验符合纳入标准。第一项研究考虑了403例患者的治疗,但在其手术研究中仅纳入了44例。这些患者被随机分为手术组和非手术组。第二项研究有25名参与者,他们被随机分配到手术组或对照组。两项研究中所有手术组参与者的神经均采用耳后入路进行减压。主要结局是12个月时面瘫的恢复情况。第一项研究表明,手术组和非手术组在9个月时面神经恢复情况相当。该研究未对两组进行统计学比较,但两组的评分和规模表明不太可能存在统计学上的显著差异。第二项研究报告其手术组和对照组之间无统计学显著差异。第一项研究中有一名接受手术的患者出现了20分贝的感音神经性听力损失和持续性眩晕。
随机对照试验提供的证据质量极低,不足以确定手术干预在贝尔面瘫治疗中是有益还是有害。由于大多数情况下会自发恢复,因此不太可能对手术干预的作用进行进一步研究。