Kohli-Kumar M, Pearson A D, Sharkey I, Craft A W
Children's Hospital Medical Center, Cincinnati, OH.
DICP. 1991 May;25(5):469-70. doi: 10.1177/106002809102500505.
Vomiting is one of the most distressing adverse effects of cancer chemotherapy. Metoclopramide by continuous infusion (400 micrograms/kg/h after a loading dose of 2.5 mg/kg) is a novel administration method for optimizing efficacy. A two-year-old boy developed urinary retention on three occasions, once accompanied by priapism and slurred speech, while receiving a continuous infusion. This was reversed by procyclidine, suggesting that it may have been a dystonic reaction.
呕吐是癌症化疗最令人痛苦的副作用之一。甲氧氯普胺持续输注（负荷剂量2.5mg/kg后以400微克/千克/小时的速度输注）是一种优化疗效的新给药方法。一名两岁男孩在接受持续输注时三次出现尿潴留，一次伴有阴茎异常勃起和言语不清。普环啶可逆转这种情况，提示这可能是一种张力障碍反应。
