糖基杂环生物分子的区域选择性简便一锅 Friedländer 合成。
Regioselective facile one-pot Friedländer synthesis of sugar-based heterocyclic biomolecules.
机构信息
Department of Organic Chemistry, University of Madras, Guindy Campus, Chennai 600 025, India.
出版信息
Carbohydr Res. 2010 Sep 23;345(14):1988-97. doi: 10.1016/j.carres.2010.07.016. Epub 2010 Jul 11.
Regioselective facile one-pot synthesis of 16 different sugar-based quinoline, naphthyridine, and xanthone derivatives is reported. The compounds are characterized by NMR spectroscopy and elemental analysis. The beta-Anomeric form of the sugar moiety was identified from (1)H NMR studies. Antimicrobial studies of these sugar-heterocyclic derivatives, 3a, 3b, 3f, 5c, 7a, 7b, and 7c show excellent activity against different microbes.
本文报道了 16 种不同糖基喹啉、萘啶和黄烷酮衍生物的区域选择性简便一锅合成法。这些化合物的结构通过 NMR 光谱和元素分析进行了表征。通过（1）H NMR 研究确定了糖部分的β-端构型。对这些糖杂环衍生物 3a、3b、3f、5c、7a、7b 和 7c 的抗菌研究表明，它们对不同的微生物具有优异的活性。
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