Saito Atsushi, Hayakawa Hiroki, Ota Kei, Fujinami Koushu, Nikaido Masahiko, Makiishi Takemi
Division of Conservative Dentistry, Department of Clinical Oral Health Science, Tokyo Dental College, Chiyoda-ku, Tokyo, Japan.
Bull Tokyo Dent Coll. 2010;51(2):85-93. doi: 10.2209/tdcpublication.51.85.
The aim of this retrospective clinical study was to evaluate the treatment of intrabony periodontal defects with enamel matrix derivative (EMD) during the early stages of healing. Sixteen patients aged 38-77 years with a clinical diagnosis of chronic periodontitis were subjected to data analysis. A total of 25 teeth with various osseous defects received regenerative therapy with EMD, and were followed for a minimum of 6 months. Post-operative healing was uneventful in the majority of cases. Treatment of the intrabony defects with EMD led to a statistically significant improvement in the mean value of probing depth at 3 months compared with that at baseline (p<0.001). Mean values of attachment gain at 3 and 6 months were of clinical significance: 3.6+/-1.8mm and 3.2+/-1.5mm, respectively. Reduction in probing depth was achieved with minimal recession of gingival margin and was sustained over a time course of 6 months. A progressive increase in radiopacity, suggestive of initial signs of bone-fill, was observed by 6 months. In summary, the results suggest that treatment of intrabony defect with EMD induces favorable periodontal healing with a high level of predictability.
这项回顾性临床研究的目的是评估在愈合早期使用釉基质衍生物（EMD）治疗骨内牙周缺损的效果。对16例年龄在38 - 77岁、临床诊断为慢性牙周炎的患者进行了数据分析。共有25颗存在各种骨缺损的牙齿接受了EMD再生治疗，并随访至少6个月。大多数病例术后愈合顺利。与基线相比，使用EMD治疗骨内缺损在3个月时探诊深度平均值有统计学意义的显著改善（p<0.001）。3个月和6个月时附着获得的平均值具有临床意义，分别为3.6±1.8mm和3.2±1.5mm。探诊深度的减小是在牙龈边缘最小退缩的情况下实现的，并且在6个月的时间过程中持续存在。到6个月时观察到阻射性逐渐增加，提示有骨填充的初始迹象。总之，结果表明用EMD治疗骨内缺损可诱导良好的牙周愈合，且具有高度可预测性。
