Lin M, Hanai J, Wada A, Ozaki M, Nasu K, Okamoto S, Matsumoto K
Second Department of Pathology, Medical School, Osaka University, Suita, Japan.
Acta Pathol Jpn. 1991 Mar;41(3):233-9.
The distribution of S-100 protein in 135 ovarian tumors, of which 127 were epithelial, was investigated using the immunoperoxidase method. S-100 protein has been demonstrated previously in tumors of various origins. The present study further revealed its characteristic distribution in common epithelial tumors of the ovary. S-100 protein was present in 69% of serous tumors (benign, 50%; borderline, 100%; malignant, 71%), as well as in the serous elements of serous & mucinous mixed tumors (30%). S-100 protein was also demonstrated in 25% of clear cell carcinomas and 29% of endometrioid carcinomas. Interestingly, none of the mucinous tumors were positive for S-100 protein. In addition, the expression of S-100 protein by epithelial ovarian tumors was compared with that of CA 125 and carcinoembryonic antigen (CEA). The distribution of S-100 protein was similar to that of CA 125, since both antigens were frequently present in serous tumors, although their expression patterns were different. On the other hand, S-100 protein-positive cases were almost negative for CEA or vice versa. Our observations indicate that demonstration of S-100 protein in common epithelial tumors of the ovary and comparison of S-100 protein distribution with that of CA 125 and CEA may further clarify the characteristics of common epithelial tumors of the ovary.
采用免疫过氧化物酶法研究了135例卵巢肿瘤（其中127例为上皮性肿瘤）中S-100蛋白的分布情况。先前已在各种起源的肿瘤中证实了S-100蛋白的存在。本研究进一步揭示了其在卵巢常见上皮性肿瘤中的特征性分布。S-100蛋白存在于69%的浆液性肿瘤中（良性，50%；交界性，100%；恶性，71%），以及浆液性和黏液性混合肿瘤的浆液成分中（30%）。S-100蛋白在25%的透明细胞癌和29%的子宫内膜样癌中也有表达。有趣的是，黏液性肿瘤中无一例S-100蛋白呈阳性。此外，还比较了卵巢上皮性肿瘤中S-100蛋白与CA 125和癌胚抗原（CEA）的表达情况。S-100蛋白的分布与CA 125相似，因为这两种抗原在浆液性肿瘤中都经常存在，尽管它们的表达模式不同。另一方面，S-100蛋白阳性的病例几乎CEA呈阴性，反之亦然。我们的观察结果表明，在卵巢常见上皮性肿瘤中检测S-100蛋白，并将S-100蛋白的分布与CA 125和CEA的分布进行比较，可能会进一步阐明卵巢常见上皮性肿瘤的特征。
